Structure of PDB 8d49 Chain A Binding Site BS01

Receptor Information
>8d49 Chain A (length=1072) Species: 1539066 (Sulfuricurvum sp. PC08-66) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FTNQYQLSKTLRFGATLKEDEKKCKSHEELKGFVDISYENMKSSATIAES
LNENELVKKCERCYSEIVKFHNAWEKIYYRTDQIAVYKDFYRQLSRKARF
DAGKQNSQLITLASLCGMYQGAKLSRYITNYWKDNITRQKSFLKDFSQQL
HQYTRALEKSDKAHTKPNLINFNKTFMVLANLVNEIVIPLSNGAISFPNI
SKLEDGEESHLIEFALNDYSQLSELIGELKDAIATNGGYTPFAKVTLNHY
TAEQKPHVFKNDIDAKIRELKLIGLVETLKGKSSEQIEEYFSNLDKFSTY
NDRNQSVIVRTQCFKYKPIPFLVKHQLAKYISEPNGWDEDAVAKVLDAVG
AIRSPAHDYANNQEGFDLNHYPIKVAFDYAWEQLANSLYTTVTFPQEMCE
KYLNSIYGCEVSKEPVFKFYADLLYIRKNLAVLEHKNNLPSNQEEFICKI
NNTFENIVLPYKISQFETYKKDILAWIHKKYTDAKQQLGFIRGGLKGYTK
LTNEFKQISSTYGKTFAELRDKFKEKNEITKITHFGIIIEDKNRDRYLLA
SELKHEQINHVSTILNKLDKSSEFITYQVKSLTKSYLLQSDTISKQSIAS
LVEGGCLLLPIINQDITSKERKDKNQFSKDWNHIFEGSKEFRLHPEFAVS
YRTPIEGYPVQKRYGRLQFVCAFNAHIVPQNGEFINLKKQIENFNDEDVQ
KRNVTEFNKKVNHALSDKEYVVIGIDRGLKQLATLCVLDKRGKILGDFEI
YKKEFVRAEKRSESHWEHTQAETRHILDLSNLRVETTIEGKKVLVDQSLT
LVKKNRDTPDEEATEENKQKIKLKQLSYIRKLQHKMQTNEQDVLDLINNE
PSDEEFKKRIEGLISSFGEGQKYADLPINTMREMISDLQGVIARGNNQTE
KNKIIELDAADNLKQGIVANMIGIVNYIFAKYSYKAYISLEDLSRAYGGA
KSGYDGRYLPSTSQDEDVDFKEQQNQMLAGLGTYQFFEMQLLKKLQKIQS
DNTVLRFVPAFRSADNYRNILRLEETKYKSKPFGVVHFIDPKFTSKKCPV
CGDDNGAYHIALKSVENLIQMK
Ligand information
>8d49 Chain B (length=26) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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...<<<<<....>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8d49 RNA targeting unleashes indiscriminate nuclease activity of CRISPR-Cas12a2.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R16 F17 G18 K22 E25 K26 K27 C28 R96 K108 N110 Q112 K378 Q495 F499 G502 T534 F537 K538 S541 K546 A549 R552 N735 Q736 S740 K741 K746 N747 Q748 F749 R774 K784 R785 Y786 F877 R883 W888 R905 V906 E907 T908 V924 K925 R928 D929 K940
Binding residue
(residue number reindexed from 1)		R12 F13 G14 K18 E21 K22 K23 C24 R92 K104 N106 Q108 K374 Q486 F490 G493 T502 F505 K506 S509 K514 A517 R520 N613 Q614 S618 K619 K624 N625 Q626 F627 R652 K662 R663 Y664 F755 R761 W766 R783 V784 E785 T786 V802 K803 R806 D807 K818
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:8d49, PDBe:8d49, PDBj:8d49
PDBsum8d49
PubMed36599980
UniProtA0A0C2W1L1

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