Structure of PDB 8d37 Chain A Binding Site BS01

Receptor Information
>8d37 Chain A (length=974) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAV
PLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPA
WAWAEGWTRYGPEGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPS
AWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTDWQEQLVVGHNVSFDRA
HIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKISSWDWLDIS
SVNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVW
ATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQGT
YEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQKKLG
PCSEEEEFQQDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCPRLD
DPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPGRRDNL
VVCPYRAIESLYRKHCLEQPSYHHGNGPYNDVDIPGCWFFKLPHKDGNSC
NVGSPFAKDFLPKMEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISS
QMVVWLPRSALPRAVIRHPDYDEEGLYGAILPQVVTAGTITRRAVEPTWL
TASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGM
HGCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQP
FAERLLMQFNHRLTQQEAAEKAQQMYAATKGLRWYRLWKGGTESEMFNKL
ESIATSDIPRTPVLGCCISRALEPSAVQEEFMTSRVNWVVQSSAVDYLHL
MLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTR
CMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPTGMERRYG
IPQGEALDIYQIIELTKGSLEKRS
Ligand information
Receptor-Ligand Complex Structure
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PDB8d37 Pol gamma coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		R579 H754 N761 V762 G763 A767 K768 N803 T861 A862 S863 N864 R869 H1134 D1135
Binding residue
(residue number reindexed from 1)		R448 H544 N551 V552 G553 A557 K558 N593 T651 A652 S653 N654 R659 H873 D874
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
4.2.99.-
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006264 mitochondrial DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0045004 DNA replication proofreading
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0000262 mitochondrial chromosome
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005760 gamma DNA polymerase complex
GO:0032991 protein-containing complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8d37, PDBe:8d37, PDBj:8d37
PDBsum8d37
PubMed37202477
UniProtP54098|DPOG1_HUMAN DNA polymerase subunit gamma-1 (Gene Name=POLG)

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