Structure of PDB 8d1g Chain A Binding Site BS01

Receptor Information
>8d1g Chain A (length=347) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYR
FVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMP
LPDALMCVVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRF
PTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSNLAAQARREGRI
RDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLAC
LIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGED
DDDFETNFLIDRNFQVSMLAVDEMYDDLAVLEKDLYWDAYTFQGSTF
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8d1g Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8d1g Structures and gating mechanisms of human bestrophin anion channels.
Resolution2.07 Å
Binding residue
(original residue number in PDB)		Q293 N296 D301 D304
Binding residue
(residue number reindexed from 1)		Q292 N295 D300 D303
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005254 chloride channel activity

View graph for
Molecular Function
External links
PDB RCSB:8d1g, PDBe:8d1g, PDBj:8d1g
PDBsum8d1g
PubMed35789156
UniProtQ8NFU1|BEST2_HUMAN Bestrophin-2a (Gene Name=BEST2)

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