Structure of PDB 8czq Chain A Binding Site BS01 |
| >8czq Chain A (length=655) Species: 1773 (Mycobacterium tuberculosis)
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SGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKS
QPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDRE
GEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQE
TRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRS
AAYWDILAKLTFSARLTAVAGRRVATGRDFDSLGTLRKEVIVLDEGSATA
LAADGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIA
QRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRK
VKQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMA
DARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVRLPHLTPGQRL
DIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGY
VHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNER
RTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDD
THGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAE
ELFAT |
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| PDB | 8czq The interaction between transport-segment DNA and topoisomerase IA-crystal structure of MtbTOP1 in complex with both G- and T-segments. |
| Resolution | 2.78 Å |
Binding residue
(original residue number in PDB) | S25 P26 T27 A29 R30 E43 S44 R46 G47 H48 D51 R54 K89 E95 R167 R168 D171 R172 G175 Y176 S179 W183 P188 K189 S191 A192 G193 R194 V195 Q196 Q332 Y342 R344 R533 S535 T536 |
Binding residue
(residue number reindexed from 1) | S10 P11 T12 A14 R15 E28 S29 R31 G32 H33 D36 R39 K74 E80 R152 R153 D156 R157 G160 Y161 S164 W168 P173 K174 S176 A177 G178 R179 V180 Q181 Q301 Y311 R313 R484 S486 T487 |
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| Enzyme Commision number |
5.6.2.1: DNA topoisomerase. |
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