Structure of PDB 8cy0 Chain A Binding Site BS01

Receptor Information
>8cy0 Chain A (length=545) Species: 1496 (Clostridioides difficile) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILY
DLFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSL
TNKKVESDIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKKFL
LEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKDLR
EYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKIKN
EDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQE
KCKYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNI
NKYIVDKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIR
KWYELQWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFIKE
EYLDKFSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRIFR
DNNYEEIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
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PDB8cy0 Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		H171 K172 K176 K179 D192 K193 I349 G351 D353 K378 K380 R425 Q438 W439 Y455 I517
Binding residue
(residue number reindexed from 1)		H139 K140 K144 K147 D160 K161 I317 G319 D321 K346 K348 R393 Q406 W407 Y423 I485
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8cy0, PDBe:8cy0, PDBj:8cy0
PDBsum8cy0
PubMed36581322
UniProtQ183J3

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