Structure of PDB 8cxz Chain A Binding Site BS01

Receptor Information
>8cxz Chain A (length=546) Species: 1496 (Clostridioides difficile) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILY
DLFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSL
TNKKVDESDIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKKF
LLEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKDL
REYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKIK
NEDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQ
EKCKYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKN
INKYIVDKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGI
RKWYELQWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFIK
EEYLDKFSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRIF
RDNNYEEIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
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PDB8cxz Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		H171 K172 K176 K179 D192 K193 I349 G351 D353 K378 K380 R425 Q438 W439 Y455 K456
Binding residue
(residue number reindexed from 1)		H140 K141 K145 K148 D161 K162 I318 G320 D322 K347 K349 R394 Q407 W408 Y424 K425
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8cxz, PDBe:8cxz, PDBj:8cxz
PDBsum8cxz
PubMed36581322
UniProtQ183J3

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