Structure of PDB 8cxv Chain A Binding Site BS01

Receptor Information
>8cxv Chain A (length=545) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILY
DLFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSL
TNKKDESDIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKKFL
LEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKDLR
EYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKIKN
EDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQE
KCKYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNI
NKYIVDKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIR
KWYELQWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFIKE
EYLDKFSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRIFR
DNNYEEIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8cxv Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Resolution2.26 Å
Binding residue
(original residue number in PDB)		Y30 N165 P166 Y168 K173 K193 Y221 S227 F253 I256 G257 F345 Q346 W439 R441 K456 Y476 K511 M513 S514 Y521 P522 N523
Binding residue
(residue number reindexed from 1)		Y3 N133 P134 Y136 K141 K161 Y189 S195 F221 I224 G225 F313 Q314 W407 R409 K424 Y444 K479 M481 S482 Y489 P490 N491
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8cxv, PDBe:8cxv, PDBj:8cxv
PDBsum8cxv
PubMed36581322
UniProtQ183J3

[Back to BioLiP]