Structure of PDB 8cxs Chain A Binding Site BS01

Receptor Information
>8cxs Chain A (length=547) Species: 1496 (Clostridioides difficile) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASGIYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDI
LYDLFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKD
SLTNKKVESDIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKK
FLLEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKD
LREYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKI
KNEDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKI
QEKCKYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSK
NINKYIVDKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSG
IRKWYELQWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFI
KEEYLDKFSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRI
FRDNNYEEIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
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PDB8cxs Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Resolution2.49 Å
Binding residue
(original residue number in PDB)		H171 K172 K179 D192 K193 I349 G351 D353 K378 K380 R425 Q438 W439 Y455 K456 A473
Binding residue
(residue number reindexed from 1)		H141 K142 K149 D162 K163 I319 G321 D323 K348 K350 R395 Q408 W409 Y425 K426 A443
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8cxs, PDBe:8cxs, PDBj:8cxs
PDBsum8cxs
PubMed36581322
UniProtQ183J3

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