Structure of PDB 8cx0 Chain A Binding Site BS01

Receptor Information
>8cx0 Chain A (length=376) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRG
QVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMAT
FLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDE
FQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNF
NNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGR
HAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVS
LCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGC
PFQPWDGLDEHSQDLSGRLRAILQNQ
Ligand information
Receptor-Ligand Complex Structure
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PDB8cx0 The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R24 I26 L27 S28 R29 N31 Y59 W94 Y124 Y125 W127 K270
Binding residue
(residue number reindexed from 1)		R18 I20 L21 S22 R23 N25 Y53 W88 Y118 Y119 W121 K264
Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008829 dCTP deaminase activity
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0002230 positive regulation of defense response to virus by host
GO:0009972 cytidine deamination
GO:0010526 retrotransposon silencing
GO:0016553 base conversion or substitution editing
GO:0016554 cytidine to uridine editing
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0048525 negative regulation of viral process
GO:0051607 defense response to virus
GO:0070383 DNA cytosine deamination
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030895 apolipoprotein B mRNA editing enzyme complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:8cx0, PDBe:8cx0, PDBj:8cx0
PDBsum8cx0
PubMed36754086
UniProtQ9HC16|ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (Gene Name=APOBEC3G)

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