Structure of PDB 8cro Chain A Binding Site BS01

Receptor Information
>8cro Chain A (length=900) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKVIGSIEFGILSPQEIRKMSAVEVTVPDTYDDDGYPIEGGVMDKRMGVI
DPGLRCETCGGRAGECPGHFGHIELARPVIHVGFAKTIYRILESTCRECG
RIKLTDEEIEEYMKKIELARNRRSEFNEIIKEIHKKAKERMVCPHCGAPQ
YPIKFEKPTIYWEIRKDEQGNEYRHRLMPTEVRDWLEKIPDKDLPLLGLD
PEKSRPEWMVLTVLPVPPVTARPSITLETGIRAEDDLTHKLVDIIRINNR
LKQNIEAGAPQLIIEDLWDLLQYHVTTYINNEAPGVPPAKHKSGRPLKTL
AQRLKGKEGRFRGNLSGKRVNFSARTVISPDPMISINEVGVPVEVAMELT
VPEKVTEFNIERLRKMVLNGPDKYPGANYVIDPEGRRRRIMDSNKETLAN
QLDIGWTVERHLMDGDIVLFNRQPSLHRMSIMAHRVRVMPYRTFRLNLAV
CPPYNADFDGDEMNLHVPQTEEAQAEARILMEVQNHIISPRYGGPIIGGI
QDHISGGYLLTREGAYFTRDEVEQMLMFAGVDITELPEPDKYDENGNPLW
SGKTIFSLLLPEDLTVWYRNKLCDEPERCEALEKLIEEKLMPDPEEVRKL
AYDGFVYIQNGKLLSGAIDKKAYGREDGIILDLIVREYGVERARQFLDQV
TKLTIWVITHKGFTTGIDDEDLPEEARDRIREIIREAEERVNKLIEAYKR
GELEPLPGKSLEDTLESLIMAVLAEARDNAGAVAEKYLGMDNHTVIMAKT
GARGKILNITQMAALLGQQSIRGKRLYRGFRGRVLSHFKPGDLGARAKGF
VVNSYKSGLTPQEYFFHAMGGREGLVDTAVRTAQSGYMQRRLINALQDLK
VEYDGTVRSPEGIIVQFKYGEDGVDPMKSWRGKTVDVDRIIVRTLLKMRG
Ligand information
Receptor-Ligand Complex Structure
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PDB8cro Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K158 P285 K308 R313 R320 R326 Q424 T833 Y838
Binding residue
(residue number reindexed from 1)		K157 P284 K307 R312 R319 R325 Q423 T832 Y837
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cro, PDBe:8cro, PDBj:8cro
PDBsum8cro
PubMed38709902
UniProtQ8U0M4

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