Structure of PDB 8cqm Chain A Binding Site BS01

Receptor Information

>8cqm Chain A (length=221) Species: 1639 (Listeria monocytogenes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

WDVNTHYWLFKQAEKILAKDVNHMRANLMNELKKFDKQIAQGIYDADHDT
STFLSHFYNPDRDPGFANAKITGAKYFNQSVTDYREGKFDTAFYKLGLAI
HYYTDISQPMHANNFTAISYPPGYHSAYENYVDTIKHNYQATEDMVAKRF
SSDDVKDWLYENAKRAKADYPKIVNAKTKKSYLVGNSEWKKDTVEPTGAR
LRDSQQTLAGFLEFWSKKTNE

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8cqm Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8cqm Structural basis for the unique molecular properties of broad-range phospholipase C from Listeria monocytogenes.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	H69 H118 D122
Binding residue (residue number reindexed from 1)	H56 H101 D105
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.1.4.3: phospholipase C.

Gene Ontology

	Molecular Function
GO:0004629	phospholipase C activity
GO:0004767	sphingomyelin phosphodiesterase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016788	hydrolase activity, acting on ester bonds
GO:0034480	phosphatidylcholine phospholipase C activity
GO:0046872	metal ion binding

	Cellular Component
GO:0005576	extracellular region

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8cqm, PDBe:8cqm, PDBj:8cqm
PDBsum	8cqm
PubMed	37838694
UniProt	P33378\|PHLC_LISMO Phospholipase C (Gene Name=plcB)

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