Structure of PDB 8cmk Chain A Binding Site BS01

Receptor Information
>8cmk Chain A (length=913) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQ
IRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSP
VIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPE
EVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVF
RCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSA
LYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTEL
CETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEH
LYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMR
VSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVD
PENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPV
LGYLMKGLAEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLDSFL
LSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEPSN
GISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKH
RADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLY
LGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDL
FRLATRFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANCSVMRFLRDL
IHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPD
VAEVLWEIMQVDRPTFCRWLENSLKGLPVTVTHKQLTDFHKQVTSAEECK
QVCWALRDFTRLF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cmk Tyrosine mediated nuclear import of CIRBP reveals a flexible NLS recognition by TNPO3
Resolution2.945 Å
Binding residue
(original residue number in PDB)		R620 E660 R664 R667 F668 R671 C699 Y702 S705 I706 D709 D747 D751 R754 R758
Binding residue
(residue number reindexed from 1)		R618 E658 R662 R665 F666 R669 C697 Y700 S703 I704 D707 D745 D749 R752 R756
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031267 small GTPase binding
GO:0042802 identical protein binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
GO:0015031 protein transport
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005642 annulate lamellae
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cmk, PDBe:8cmk, PDBj:8cmk
PDBsum8cmk
PubMed
UniProtQ9Y5L0|TNPO3_HUMAN Transportin-3 (Gene Name=TNPO3)

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