Structure of PDB 8cmc Chain A Binding Site BS01

Receptor Information
>8cmc Chain A (length=182) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGR
FASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELR
EPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHY
LPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDA
Ligand information
>8cmc Chain C (length=14) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
VLSFELLHAPATVC
Receptor-Ligand Complex Structure
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PDB8cmc Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4 + T cell immunity.
Resolution1.42 Å
Binding residue
(original residue number in PDB)		Q9 F51 A52 S53 G58 A59 N62 V65 N69 I72 R76
Binding residue
(residue number reindexed from 1)		Q9 F51 A52 S53 G58 A59 N62 V65 N69 I72 R76
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:8cmc, PDBe:8cmc, PDBj:8cmc
PDBsum8cmc
PubMed37471227
UniProtP01903|DRA_HUMAN HLA class II histocompatibility antigen, DR alpha chain (Gene Name=HLA-DRA)

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