Structure of PDB 8cls Chain A Binding Site BS01

Receptor Information
>8cls Chain A (length=837) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTMRLSQNVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLNR
SFPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNF
DLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTE
NGKEKQLHNNRRLCWNSKLCQTKCPEKCRNNCIDEHTCCSQDCLGGCVID
KNGNESCISCRNVSFNNICMDSCPKGYYQFDSRCVTANECITLTKFETNS
VYSGIPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKECSSGLIDSLER
AREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHL
TYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQTVFIR
KGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTA
VLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYH
MIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMA
ISSELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYG
VLTRYFIKAKLINRPTRNNNRDYCTEPLGMEFENALQNFIFVPNKDDENT
YKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEI
PSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESP
VRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIK
LNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAK
Ligand information
>8cls Chain C (length=24) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DFRGVVDSCCRNSCSFSTLRAYCD
Receptor-Ligand Complex Structure
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PDB8cls Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		S881 N1037 N1041 F1044 P1046 N1047
Binding residue
(residue number reindexed from 1)		S524 N634 N638 F641 P643 N644
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:8cls, PDBe:8cls, PDBj:8cls
PDBsum8cls
PubMed37805602
UniProtP09208|INSR_DROME Insulin-like receptor (Gene Name=InR)

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