Structure of PDB 8ciz Chain A Binding Site BS01

Receptor Information
>8ciz Chain A (length=364) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRMKFTVEREHLLKPLQQVSGPPTLPILGNLLLQVADGTLSLTGTDLEME
MVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSG
RSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVR
YYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIE
LMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNP
DKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEA
EEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDA
ASQSAAYVVMPMRL
Ligand information
>8ciz Chain C (length=10) Species: 135947 (Actinoplanes awajinensis subsp. mycoplanecinus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
VPTLKPVPLG
Receptor-Ligand Complex Structure
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PDB8ciz Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins
Resolution2.27 Å
Binding residue
(original residue number in PDB)		G174 H175 R176 L177 M362 P363 M364 R365
Binding residue
(residue number reindexed from 1)		G172 H173 R174 L175 M360 P361 M362 R363
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006974 DNA damage response
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032297 negative regulation of DNA-templated DNA replication initiation
GO:0042276 error-prone translesion synthesis
GO:0044787 bacterial-type DNA replication
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009360 DNA polymerase III complex
GO:0030894 replisome
GO:1990078 replication inhibiting complex
GO:1990085 Hda-beta clamp complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ciz, PDBe:8ciz, PDBj:8ciz
PDBsum8ciz
PubMed38278788
UniProtP0A988|DPO3B_ECOLI Beta sliding clamp (Gene Name=dnaN)

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