Structure of PDB 8cir Chain A Binding Site BS01

Receptor Information
>8cir Chain A (length=339) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQ
DTKGFSTWLKLNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQR
LFFLQVKEGILNDDIYCPPETAVLLASYAVQSKYGDFNKEVHKSGYLAGD
KLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQDLEM
YGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISF
NDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI
EVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEK
Ligand information
>8cir Chain C (length=14) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GGSWKYPDAFELSG
Receptor-Ligand Complex Structure
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PDB8cir The FERM domain of human moesin with a bound peptide identified by phage display
Resolution1.85 Å
Binding residue
(original residue number in PDB)		K27 Q28 F30 W43 L61 N62 K83 F84 E289 L290 R293
Binding residue
(residue number reindexed from 1)		K27 Q28 F30 W43 L61 N62 K83 F84 E289 L290 R293
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0008092 cytoskeletal protein binding
Cellular Component
GO:0005856 cytoskeleton

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8cir, PDBe:8cir, PDBj:8cir
PDBsum8cir
PubMed37866628
UniProtP26038|MOES_HUMAN Moesin (Gene Name=MSN)

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