Structure of PDB 8ce5 Chain A Binding Site BS01

Receptor Information

>8ce5 Chain A (length=202) Species: 83333 (Escherichia coli K-12)

GMLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTG
LSRPDAGEVLWQGQPLHQVRDSYHQNLLWIGHQPGIKTRLTALENLHFYH
RDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWI
LDQPFTAIDVNGVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRISL
TQ

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8ce5 Chain A Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ce5 Architecture of the Heme-translocating CcmABCD/E complex required for Cytochrome c maturation.
• Resolution: 3.62 Å
• Binding residue (original residue number in PDB): T43 H83
• Binding residue (residue number reindexed from 1): T42 H82
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.6.2.5: ABC-type heme transporter.

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0015439 ABC-type heme transporter activity
• GO:0016887 ATP hydrolysis activity
• GO:0022857 transmembrane transporter activity

Biological Process

• GO:0017004 cytochrome complex assembly
• GO:1903607 cytochrome c biosynthetic process
• GO:1904334 heme import across plasma membrane

Cellular Component

• GO:0005886 plasma membrane
• GO:0043190 ATP-binding cassette (ABC) transporter complex

External links

• PDB: RCSB:8ce5, PDBe:8ce5, PDBj:8ce5
• PDBsum: 8ce5
• PubMed: 37626034
• UniProt: P33931|CCMA_ECOLI Cytochrome c biogenesis ATP-binding export protein CcmA (Gene Name=ccmA)