Structure of PDB 8c9e Chain A Binding Site BS01

Receptor Information
>8c9e Chain A (length=921) Species: 1404 (Priestia megaterium) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEYKDTLLMPKTEFPMRGNLPNREPKMQEQWAEMNIYEKVQKRTEGRPLF
VLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGFCAPYVPGWDTHGLP
IETALTKNKKVNRKEMTVAEFRKLCEQYAWEQVNGQREQFKRLGVRGDWD
NPYVTLQPQYEAQQIKVFGDMAKKGYIYKGLKPVYWSPSSESALAEAEIE
YYDKRSASIYVAFNVKDGKGVLEQDEKFIIWTTTPWTMPANQGIAVNPEL
QYSVVEADGAKYVVATELIETVAKEIEWADYKTLRTVKGSELERVVAEHP
IYKRDSLVVLGDHVTTDAGTGCVHTAPGHGEDDFIVGQKYGLEVLCPVDS
KGHMTNEAPGFEGLFYDKANKPITDKLEEEGALLKLSFITHSYPHDWRTK
KPTIFRATAQWFASIKDFREDLLKAVEKTKWVPTWGETRLYNMVRDRGDW
CISRQRAWGVPIPVFYAENEEPIITDETIEHVSNLFREHGSNVWFEREAK
DLLPEGFTHEGSPNGRFTKETDIMDVWFDSGSSHQAVLEEREDLQRPADL
YLEGSDQYRGWFNSSLSTSVAVTGEAPYKGVLSHGFALDGEGRKMSKSLG
NVVIPEKVMKQLGADILRLWVASVDYQADVRVSDNILKQVAEVYRKIRNT
FRFLLGNLADFNPTTDAVAVEDLREVDRYMLVKLNKLIDKVKKSYDSYEF
SSIYHAVHNFCTIDMSSFYLDFAKDVLYIEAENNVERRSIQTVLYETLLS
LTKLVSPILSHTADEVWVHIPNVTEESVQLVDMPEVQEIEGADQLVEKWD
AFMELRDEVLKALEQARNEKVIGKSLEAKLTLYPTADTKELLASISENVG
QLFIVSDLEVAEGEAPAEAQKFSYASIVVSKAEGEKCERCWVVSPTVGED
QDHPTLCTRCADVVKNHYVQQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8c9e Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8c9e Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif
Resolution2.9 Å
Binding residue
(original residue number in PDB)		C887 C890 C907 C910
Binding residue
(residue number reindexed from 1)		C887 C890 C907 C910
Annotation score1
Enzymatic activity
Enzyme Commision number 6.1.1.5: isoleucine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004822 isoleucine-tRNA ligase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006428 isoleucyl-tRNA aminoacylation
GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c9e, PDBe:8c9e, PDBj:8c9e
PDBsum8c9e
PubMed37679387
UniProtA0A0B6A6A8

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