Structure of PDB 8c8j Chain A Binding Site BS01

Receptor Information

>8c8j Chain A (length=698) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KLNNLLLNDYWVHNEMKAEIKMFFETNENKDTTYQNLWDAFKAVCRGKFI
ALNANQIDTIKNDKGDITTDPTEIQTTIREYYKHLYANKLENLEEMDTFL
DTYTLPRLNQEEVESLNRPITGSEIVAIINSLPTKKSPGPDGFTAEFYQR
YKEELVPFLLKLFQSIEKEGILPNSFYEASIILIPKPGRDTTKKENFRPI
SLMNIDAKILNKILANRIQQHIKKLIHHDQVGFIPGMQGWFNIRKSINVI
QHINRAKDKNHMIISIDAEKAFDKIQQPFMLKTLNKLGIDGTYFKIIRAI
YDKPTANIILNGQKLEAFPLKTGTRQGCPLSPLLFNIVLEVLARAIRQEK
EIKGIQLGKEEVKLSLFADDMIVYLENPIVSAQNLLKLISNFSKVSGYKI
NVQKSQAFLYTNNRQTESQIMGELPFTIASKRIKYLGIQLTRDVKDLFKE
NYKPLLKEIKEETNKWPCSWVGRINIVKMAILPKVIYRFNAIPIKLPMTF
FTELEKTTLKFIWNQTLPDFKLYYKATVTKTAWYWYQNRDIDQWNRTEPS
YNYLIFDKPEKNGKDSLFNKWCWENWLAICRKLKLDPFLTPYTKINSRWI
KDLNVKPKTIKTLEENLGITIQDIGVGKDFMSKTPKAMATKDKIDKWDLI
KLKSFCTAKETTIRVNRQPTTWEKIFATYSSDKGLISRIYNELKQIYH

Ligand information

>8c8j Chain B (length=9) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gcgctttcc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8c8j Long Interspersed Nuclear Element 1 (LINE-1) reverse transcriptase ternary complex with hybrid duplex and dTTP
Resolution	2.1 Å
Binding residue (original residue number in PDB)	F566 F700 D703 L769 G770 M815 P819 K820 Y823
Binding residue (residue number reindexed from 1)	F233 F367 D370 L436 G437 M479 P483 K484 Y487

Enzymatic activity

Enzyme Commision number

2.7.7.49: RNA-directed DNA polymerase.
3.1.21.-

External links

PDB	RCSB:8c8j, PDBe:8c8j, PDBj:8c8j
PDBsum	8c8j
PubMed	38096902
UniProt	O00370\|LORF2_HUMAN LINE-1 retrotransposable element ORF2 protein

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