Structure of PDB 8c4v Chain A Binding Site BS01

Receptor Information
>8c4v Chain A (length=1308) Species: 11602 (Hantaan virus 76-118) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YIPDYKGMEPIGANIEDLVDYSKDWLSRARNFSFFEVKGTAVFECFNSNE
ANHCQRYPMSRKPRNFLLIQCSLITSYKPATTLSDQIDSRRACSYILNLI
PDTPASYLIHDMAYRYINLTREDMINYYAPRIQFKQTQNVREPGTFKLTS
SMLRAESKAMLDLLNNQIESLNIASHIVQSESVSLITKILSDLELNITTV
LDKFFQNETQKYLIDVLKKTTAWHIGHLIRDITESLIAHSGLKRSKYWSL
HSYNNGNVILFILPSKSLEVAGSFIRFITVFRIGPGLVDKDNLDTILIDG
DSQWGVSKVMSIDLNRLLALNIAFEKALIATATWFQYYTEDQGQFPLQYA
IRSVFANHFLLAICQKMKLCAIFDNLRYLIPAVTSLYSGFPSLIEKLFER
PFKSSLEVYIYYNIKSLLVALAQNNGVYPSFMSRIVYKHYRSLISEVTTC
FFLFEKGLHGNMNEEAKIHLETVEWALKFREKEEKYGESLVENGYMMWEL
RANAELAEQQLYCQDAIELAAIELNKVLATKSSVVANSILSKNWEEPYFS
QTRNISLKGMSGQVQEDGHLSSSVTIIEAIRYLSNSRHNPSLLKLYEETR
EQKAMARIVRKYQRTEADRGFFITTLPTRCRLEIIEDYYDAIAKNISEEY
ISYGGEKKILAIQGALEKALRWASGESFIELSNHKFIRMKRKLMYVSADA
TKWSPGDNSAKFRRFTSMLHNGLPNNKLKNCVIDALKQVYKTDFFMSRKL
RNYIDSMESLDPHIKQFLDFFPDGHHGEVKGNWLQGNLNKCSSLFGVAMS
LLFKQVWTNLFPELDCFFEFAHHSDDALFIYGYLEPVDDGTDWFLFVSQQ
IQAGHLHWFSVNTEMWKSMFNLHEHILLLGSIKISPKKTTVSPTNAEFLS
TFFEGCAVSIPFVKILLGSLSDLPGLGYFDDLAAAQSRCVKALDLGASPQ
VAQLAVALCTSKVERLYGTAPGMVNHPAAYLQVKHTDTPIPLGGNGAMSI
MELATAGIGMSDKNLLKRALLGYSHKRQKSMLYILGLFKFLMKLSDETFQ
HERLGQFSFIGKVQWKIFTPKSEFEFADMYTSKFLELWSSQHVTYDYIIP
KGRDNLLIYLVRKLNDPSIVTAMTMQSPLQLRFRMQAKQHMKVCRLDGEW
VTFREVLAAANSFAENYSATSQDMDLFQTLTWKDFLNGIHCDVIPTKQVQ
RAKVARTFTVRESIPAVIGYKFAVTVEEMSDVLDTAKFPDSLSVDLKTMK
DGVYRELGLDISLPDVMKRIAPMLYKSRVVIVQGNVEGTAEAICRYWLKS
MSLVKTIR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8c4v Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication.
Resolution3.14 Å
Binding residue
(original residue number in PDB)		R281 Y282 L388 L389 Q401 I402 K496 K516 G522 F524 R526 K558 V559 M560 S561 R566 K616 M617 K618 P651 K653 G733 N734 N736 Y1026 I1027 M1030 S1032 L1033 D1034 H1036 I1037 F1040
Binding residue
(residue number reindexed from 1)		R56 Y57 L163 L164 Q167 I168 K246 K266 G272 F274 R276 K308 V309 M310 S311 R316 K366 M367 K368 P401 K403 G460 N461 N463 Y753 I754 M757 S759 L760 D761 H763 I764 F767
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004519 endonuclease activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044220 host cell perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c4v, PDBe:8c4v, PDBj:8c4v
PDBsum8c4v
PubMed37221161
UniProtP23456|L_HANTV RNA-directed RNA polymerase L (Gene Name=L)

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