Structure of PDB 8c4t Chain A Binding Site BS01

Receptor Information
>8c4t Chain A (length=1268) Species: 11602 (Hantaan virus 76-118) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YIPDYKGMEPIGANIEDLVDYSKDWLSRARNFSFFEVKGTAVFECFNSNE
ANHCQRYPMSRKPRNFLLIQCSLITSYKPATTLSDQIDSRRACSYILNLI
PDTPASYLIHDMAYRYINLTREDMINYYAPRIQFKQTQNVREPGTFKLTS
SMLRAESKAMLDLLNNQIESLNIASHIVQSESVSLITKILSDLELNITTV
LDKFFQNETQKYLIDVLKKTTAWHIGHLIRDITESLIAHSGLKRSKYWSL
HSYNNGNVILFILPSKSLEVAGSFIRFITVFRIGPGLVDKDNLDTILIDG
DSQWGVSKVMSIDLNRLLALNIAFEKALIATATWFQYYTEDQGQFPLQYA
IRSVFANHFLLAICQKMKLCAIFDNLRYLIPAVTSLYSGFPSLIEKLFER
PFKSSLEVYIYYNIKSLLVALAQNVYPSFMSRIVYKHYRSLISEVTTCFF
LFEKGLHGNMNEEAKIHLETVEWALKFREKEEKYGESLVENGYMMWELRA
NAELAEQQLYCQDAIELAAIELNKVLATKSSVVANSILSKNWEEPYFSQT
RNISLKGMSGQVQEDGHLSSSVTIIEAIRYLSNSRHNPSLLKLYEETREQ
KAMARIVRKYQRTEADRGFFITTLPTRCRLEIIEDYYDAIAKNISEEYIS
YGGEKKILAIQGALEKALRWASGESFIELSFIRMKRKLMYVSADATKWSP
GDNSAKFRRFTSMLHNGLPNNKLKNCVIDALKQVYKTDFFMSRKLRNYID
SMESLDPHIKQFLDFFPDGHHGEVKGNWLQGNLNKCSSLFGVAMSLLFKQ
VWTNLFPELDCFFEFAHHSDDALFIYGYLEPVDWFLFVSQQIQAGHLHWF
SVNTEMWKSMFNLHEHILLLGSIKISPKKTTVSPTNAEFLSTFFEGCAVS
IPFVKILLGSLSDLPGLGYFDDLAAAQSRCVKALDLGASPQVAQLAVALC
TSKVERLYGTAPGMVNHPAAYLQVKHTDTPIPLGGNGAMSIMELATAGIG
MSDKNLLKRALLGYSHKRQKSMLYILGLFKFLMKLSDETFQFSFIGEFEF
ADMYTSKFLELWSSQHVTYDYIIPKGRDNLLIYLVRKLNDPSIVTAMLQL
RFRMQAKQHMKVCRLDGEWVTFREVLAAANSFAENYSATSQDMDLFQTLT
SCTAWKDFLNGIHCDVIPTKQVQRAKVARTFTSIPAVIGYKFAVTVEEMS
DVLDTAKFPDSLSVDLKTMKDGVYRESLPDVMKRIARVVIVQGNVEGTAE
AICRYWLKSMSLVKTIRV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8c4t Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication.
Resolution3.23 Å
Binding residue
(original residue number in PDB)		R281 Y282 K287 R289 L389 N391 I402 G522 F524 K558 V559 S561 R566 K616 M617 K618 K653 G733 N736 A739 Y1026 I1027 M1030 S1032 D1034 I1037 F1040
Binding residue
(residue number reindexed from 1)		R56 Y57 K62 R64 L164 N166 I168 G272 F274 K308 V309 S311 R316 K366 M367 K368 K403 G458 N461 A464 Y748 I749 M752 S754 D756 I759 F762
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004519 endonuclease activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044220 host cell perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c4t, PDBe:8c4t, PDBj:8c4t
PDBsum8c4t
PubMed37221161
UniProtP23456|L_HANTV RNA-directed RNA polymerase L (Gene Name=L)

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