Structure of PDB 8c1n Chain A Binding Site BS01

Receptor Information

>8c1n Chain A (length=474) Species: 12110 (Foot-and-mouth disease virus)

GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAAAK

Ligand information

>8c1n Chain C (length=17) Species: 12110 (Foot-and-mouth disease virus)

GPLERQRPLKVRAKLPR

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8c1n Dual role of the foot-and-mouth disease virus 3B1 protein in the replication complex: As protein primer and as an essential component to recruit 3Dpol to membranes.
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): R320 H322 Y323 E324 Y346
• Binding residue (residue number reindexed from 1): R320 H322 Y323 E324 Y346

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:8c1n, PDBe:8c1n, PDBj:8c1n
• PDBsum: 8c1n
• PubMed: 37126532
• UniProt: P03311|POLG_FMDVS Genome polyprotein