Structure of PDB 8c17 Chain A Binding Site BS01
Receptor Information
>8c17 Chain A (length=220) Species:
9606
(Homo sapiens) [
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GPRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEA
VDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFY
GVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRS
PLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYV
FEVSASEHGAQHHIYRLVKE
Ligand information
>8c17 Chain B (length=16) Species:
32630
(synthetic construct) [
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FSPGDFHLDIGCDVGR
Receptor-Ligand Complex Structure
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PDB
8c17
Biochemical and Structural Characterization of a Peptidic Inhibitor of the YAP:TEAD Interaction That Binds to the alpha-Helix Pocket on TEAD.
Resolution
2.25 Å
Binding residue
(original residue number in PDB)
S336 F337 V341 Y369 F373 K376 L377 L380 S388 V389 N392 F393
Binding residue
(residue number reindexed from 1)
S122 F123 V127 Y155 F159 K162 L163 L166 S174 V175 N178 F179
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:8c17
,
PDBe:8c17
,
PDBj:8c17
PDBsum
8c17
PubMed
36825662
UniProt
Q15561
|TEAD4_HUMAN Transcriptional enhancer factor TEF-3 (Gene Name=TEAD4)
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