Structure of PDB 8bw7 Chain A Binding Site BS01

Receptor Information
>8bw7 Chain A (length=497) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCR
PPANANLSKDGGLEAWLPLDKQGQPESCLRFTSTEPCIDGWVYDNSTFPS
TIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILN
YLQTAVSGTCAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHT
RAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVPFFIAFIYSWFF
IESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTSLQSAME
LLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVD
LPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHTIIRTSLAV
LGKGCLASSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMT
AEFYPSMPLFIFGAVPVVASAVTALLPETLGQPLPDTVQDLKSRSRG
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain8bw7 Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8bw7 Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Resolution3.53 Å
Binding residue
(original residue number in PDB)		G227 Y230 K382
Binding residue
(residue number reindexed from 1)		G209 Y212 K354
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005452 solute:inorganic anion antiporter activity
GO:0005515 protein binding
GO:0008514 organic anion transmembrane transporter activity
GO:0015132 prostaglandin transmembrane transporter activity
GO:0015139 alpha-ketoglutarate transmembrane transporter activity
GO:0015297 antiporter activity
GO:0015347 sodium-independent organic anion transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0031404 chloride ion binding
GO:0042802 identical protein binding
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0006820 monoatomic anion transport
GO:0014070 response to organic cyclic compound
GO:0015698 inorganic anion transport
GO:0015711 organic anion transport
GO:0015732 prostaglandin transport
GO:0015742 alpha-ketoglutarate transport
GO:0042908 xenobiotic transport
GO:0043252 sodium-independent organic anion transport
GO:0055085 transmembrane transport
GO:0072237 metanephric proximal tubule development
GO:0097254 renal tubular secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8bw7, PDBe:8bw7, PDBj:8bw7
PDBsum8bw7
PubMed37482561
UniProtO35956|S22A6_RAT Solute carrier family 22 member 6 (Gene Name=Slc22a6)

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