Structure of PDB 8bty Chain A Binding Site BS01

Receptor Information

>8bty Chain A (length=934) Species: 1311 (Streptococcus agalactiae)

TSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKT
KARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTH
VSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAI
RDAINLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGND
SSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETVRVKTA
QDKEMPVLSTNRFEPNKAYDYAYANRGTKEDDFKDVKGKIALIERGDIDF
KDKIAKAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKD
NPQKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILS
SVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKV
LMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVH
LNNVSDKFEVTVNVHNKSDKPQELYYQATVQTDKVDGKHFALAPKVLYEA
SWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFKQDPKK
EELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQLDGDG
LQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETILAGTF
AKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAE
VLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVV
ANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRRLT
LASKPKTSQPVYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETTEG
ATVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHS

Ligand information

>8bty Chain B (length=4) Species: 1311 (Streptococcus agalactiae)

APQA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8bty The 1.7 angstrom crystal structure of the C5a peptidase from Streptococcus agalactiae (ScpB) reveals an active site competent for catalysis.
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): R393 D397 F398 I425
• Binding residue (residue number reindexed from 1): R295 D299 F300 I327

Enzymatic activity

• Enzyme Commision number: 3.4.21.110: C5a peptidase.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005618 cell wall
• GO:0016020 membrane

External links

• PDB: RCSB:8bty, PDBe:8bty, PDBj:8bty
• PDBsum: 8bty
• PubMed: 37921533
• UniProt: Q53637