Structure of PDB 8btl Chain A Binding Site BS01

Receptor Information
>8btl Chain A (length=354) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEELENKPRKQQGYST
VSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPE
SAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTG
GGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESA
FEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRL
TDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRH
NDMPIYEAADKALKTFQEEFMPVETFSEFLDVAGLLSEITDPESFLKDLL
NSVP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8btl Chain A Residue 5201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8btl An Atypical E3 Ligase Module in UBR4 Mediates Destabilization of N-degron Substrates
Resolution3.2 Å
Binding residue
(original residue number in PDB)		C4838 H4887 C4890
Binding residue
(residue number reindexed from 1)		C9 H58 C61
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
External links
PDB RCSB:8btl, PDBe:8btl, PDBj:8btl
PDBsum8btl
PubMed38182926
UniProtQ5T4S7|UBR4_HUMAN E3 ubiquitin-protein ligase UBR4 (Gene Name=UBR4)

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