Structure of PDB 8bf5 Chain A Binding Site BS01

Receptor Information
>8bf5 Chain A (length=697) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVISL
RPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKYLADLFDYKTKRFIEVGI
TKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLSNESSLDEEGKGRVLSR
LTELQAELSLKNLWQVLIGEEDVEKGIDFKLGQTISRLRDISVPAGFSNF
EGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKLTWEDLRPIGPHIYNHE
LPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAKECLEKYSTLRDQTDPI
LIMKSEKANENFLWKLWRDCVNTISNEEMSNELQKTNYAKWATGDGLTYQ
KIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTEMNLLSTLTSKRALDLPE
IGPDVAPVEHVGSERRKYFVNEINYCKASTVMMKYVLFHTSLLNESNASM
GKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHLRGDTDVVTVVTFEFSS
TDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYCRVNGTNKIQMKWGMEA
RRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGDRVNSPKTFSIGTQEGK
LVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAESRRLLLLIQALKDRKG
PWVFDLEGMYSGIEECISNNPWVIQSAYWFNEWLGFEKEGSKVLESV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8bf5 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Resolution2.96 Å
Binding residue
(original residue number in PDB)		K330 T366 G367 D368 G369 L370 T371 P391 K392 I393 Q504 H506 R508 V513 T515 R558 V559 N560 G561 N648 N692
Binding residue
(residue number reindexed from 1)		K307 T343 G344 D345 G346 L347 T348 P368 K369 I370 Q481 H483 R485 V490 T492 R535 V536 N537 G538 N625 N669
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bf5, PDBe:8bf5, PDBj:8bf5
PDBsum8bf5
PubMed36596301
UniProtQ5V8Z9

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