Structure of PDB 8bf1 Chain A Binding Site BS01

Receptor Information
>8bf1 Chain A (length=262) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSL
MMGEDKIKEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLND
QVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDF
MEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNL
LQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDM
SLHPLLQEIYKD
Ligand information
Receptor-Ligand Complex Structure
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PDB8bf1 Structural basis of the activation of PPAR gamma by the plasticizer metabolites MEHP and MINCH.
Resolution1.36 Å
Binding residue
(original residue number in PDB)		K301 L311 N312 Q314 P467 L468 E471
Binding residue
(residue number reindexed from 1)		K88 L98 N99 Q101 P254 L255 E258
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bf1, PDBe:8bf1, PDBj:8bf1
PDBsum8bf1
PubMed36841188
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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