Structure of PDB 8be0 Chain A Binding Site BS01

Receptor Information
>8be0 Chain A (length=722) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVISD
MNFLDEEGKAYTALEGQGKEQNLRPQYEVIEGMPRTIAWMVQRSLAQEHG
IETPKYLADLFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSY
NQDYSLSNESSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDVEKGI
DFKLGQTISRLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLV
SVTPKKLTWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSK
KPKTLAKECLEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNE
EMSNELQKTNYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVA
AWVQTEMNLLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCK
ASTVMMKYVLFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLA
VKGQSHLRGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGRE
KSVYLYCRVNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMT
KACFKGDRVNSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQ
LEGFSAESRRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSA
YWFNEWLGFEKEGSKVLESVDE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8be0 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Resolution2.34 Å
Binding residue
(original residue number in PDB)		K330 T366 G367 D368 G369 L370 T371 K392 I393 P394 H506 R508 V513 T515 V559 N560 G561
Binding residue
(residue number reindexed from 1)		K330 T366 G367 D368 G369 L370 T371 K392 I393 P394 H506 R508 V513 T515 V559 N560 G561
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8be0, PDBe:8be0, PDBj:8be0
PDBsum8be0
PubMed36596301
UniProtQ5V8Z9

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