Structure of PDB 8b8z Chain A Binding Site BS01
Receptor Information
>8b8z Chain A (length=262) Species:
9606
(Homo sapiens) [
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HMQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIY
DMNSLMMGEDKIKFKHIQSKEVAIRIFQGAQFRSVEAVQEITEYAKSIPG
FVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKS
LRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKP
IEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQV
IKKTETHPLLQE
Ligand information
>8b8z Chain C (length=11) Species:
9606
(Homo sapiens) [
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GLEAIIRKALM
Receptor-Ligand Complex Structure
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PDB
8b8z
Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.
Resolution
2.22 Å
Binding residue
(original residue number in PDB)
V293 T297 K301 V315 K319
Binding residue
(residue number reindexed from 1)
V88 T92 K96 V110 K114
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0004879
nuclear receptor activity
Biological Process
GO:0006355
regulation of DNA-templated transcription
Cellular Component
GO:0005634
nucleus
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Molecular Function
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Cellular Component
External links
PDB
RCSB:8b8z
,
PDBe:8b8z
,
PDBj:8b8z
PDBsum
8b8z
PubMed
36542958
UniProt
P37231
|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)
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