Structure of PDB 8b77 Chain A Binding Site BS01

Receptor Information
>8b77 Chain A (length=1110) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLT
NMHATLVSQEQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVND
VEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFE
ARKLLRPILQDNANNNVQRNIYNVKVDAKHLIEDIREYDVPYHVRVSIDK
DIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFAIATTKPPLKFPDSAVDQ
IMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVA
LLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPD
AEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPE
LMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDET
LRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGH
VESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKV
TNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPD
SIKAERDCASCDFKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPL
SYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKS
FRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAHKVI
LVSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDT
DGIWCILPKSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQEL
KDPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDG
SLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRW
LDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDF
LGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRW
TLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEH
PDWLKRKIAT
Ligand information
Receptor-Ligand Complex Structure
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PDB8b77 A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		P433 Q434 D875 T876 K967 Y969 K982 G983 K987 R988 R989 S1053 Y1059 Q1062
Binding residue
(residue number reindexed from 1)		P376 Q377 D799 T800 K891 Y893 K906 G907 K911 R912 R913 S977 Y983 Q986
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b77, PDBe:8b77, PDBj:8b77
PDBsum8b77
PubMed37819038
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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