Structure of PDB 8b6z Chain A Binding Site BS01

Receptor Information

>8b6z Chain A (length=442) Species: 9606 (Homo sapiens)

EKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGS
FKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMI
TGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVN
KMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLE
PSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDV
YKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEAL
PGDNVGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQI
SAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVE
MVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKS

Ligand information

>8b6z Chain B (length=8)

uacgagag

........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8b6z Visualization of translation and protein biogenesis at the ER membrane.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): R266 R423 A425 R427
• Binding residue (residue number reindexed from 1): R263 R420 A422 R424

Gene Ontology

Molecular Function

• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005515 protein binding
• GO:0005525 GTP binding
• GO:0008135 translation factor activity, RNA binding
• GO:0019901 protein kinase binding

Biological Process

• GO:0006412 translation
• GO:0006414 translational elongation
• GO:0043065 positive regulation of apoptotic process
• GO:0090218 positive regulation of lipid kinase activity
• GO:1904714 regulation of chaperone-mediated autophagy

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005853 eukaryotic translation elongation factor 1 complex
• GO:0045202 synapse
• GO:0098574 cytoplasmic side of lysosomal membrane

External links

• PDB: RCSB:8b6z, PDBe:8b6z, PDBj:8b6z
• PDBsum: 8b6z
• PubMed: 36697828
• UniProt: Q05639|EF1A2_HUMAN Elongation factor 1-alpha 2 (Gene Name=EEF1A2)