Structure of PDB 8b67 Chain A Binding Site BS01

Receptor Information
>8b67 Chain A (length=1085) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGW
LTNMHATLVSQENQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESR
VNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQ
LFEARKLLRPILQDNQRNIYNVDAKHLIEDIREYDVPYHVRVSIDKDIRV
GKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAVDQIMMI
SYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALLQR
FFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAEGE
YKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELMTP
YAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLRKG
TGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVESL
EAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTNFE
EIKNQITQKLLELKENNIRNELPLIYHVDVASGYPNIMTTNRLQPDSIKA
ERDCTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNVLTFDELSYA
DQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFRD
RRYEFKGLAKTMIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGIT
CLTGATIIQMARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKK
LYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPY
KAMILPSSKEEGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQS
DIFKVFLEGDTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENR
SMSKTLKEYEGQKSTSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNA
PVTERAIPVAIFSADIPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERL
GSAIQKIITIPAALQGVSNPVPRVEHPDWLKRKIA
Ligand information
Receptor-Ligand Complex Structure
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PDB8b67 A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		Q434 R749 K751 D875 T876 K967 Y969 K982 G983 K987 R988 R989 S1053 Y1059
Binding residue
(residue number reindexed from 1)		Q373 R670 K672 D775 T776 K867 Y869 K882 G883 K887 R888 R889 S953 Y959
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b67, PDBe:8b67, PDBj:8b67
PDBsum8b67
PubMed37819038
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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