Structure of PDB 8b5w Chain A Binding Site BS01

Receptor Information
>8b5w Chain A (length=346) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPGLTCCICREGYKFQPTKVLGIYTFTKRVALEELENKPRKQQGYSTVSH
FNIVHYDCHLAAVREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLA
RHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNI
HLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYY
FTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDY
SAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEA
ADKALKTFQEEFMPVETFSEFLDVAGLLSEITDPESFLKDLLNSVP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8b5w Chain A Residue 5201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8b5w Crystal structure of the E3 module from UBR4
Resolution1.8 Å
Binding residue
(original residue number in PDB)		C4838 C4841 H4887 C4890
Binding residue
(residue number reindexed from 1)		C6 C9 H55 C58
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
External links
PDB RCSB:8b5w, PDBe:8b5w, PDBj:8b5w
PDBsum8b5w
PubMed38182926
UniProtQ5T4S7|UBR4_HUMAN E3 ubiquitin-protein ligase UBR4 (Gene Name=UBR4)

[Back to BioLiP]