Structure of PDB 8b4x Chain A Binding Site BS01

Receptor Information

>8b4x Chain A (length=473) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEK
NHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANN
GVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPED
DGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGY
TNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQ
KCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNA
NDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEP
KDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSP
MGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEAN
NYGTLTKFTLVLYGTASGSLVPR

Ligand information

>8b4x Chain B (length=5) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gRVKG

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8b4x Aminoisoindol-based furin inhibitors
Resolution	1.6 Å
Binding residue (original residue number in PDB)	D154 V231 E236 S253 W254 G255 P256 D258 D264 A292 G294 D306 Y308 S368
Binding residue (residue number reindexed from 1)	D46 V123 E128 S145 W146 G147 P148 D150 D156 A184 G186 D198 Y200 S260

Enzymatic activity

Enzyme Commision number

3.4.21.75: furin.

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:8b4x, PDBe:8b4x, PDBj:8b4x
PDBsum	8b4x
PubMed	38385828
UniProt	P09958\|FURIN_HUMAN Furin (Gene Name=FURIN)

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