Structure of PDB 8b1b Chain A Binding Site BS01

Receptor Information
>8b1b Chain A (length=451) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QQPRPFFMIFFVELWERFGYYGVQGVLAVFFVKQLGFSQEQAFVTFGAFA
ALVYGLISIGGYVGDHLLGTKRTIVLGALVLAIGYFMTGMSLLKPDLIFI
ALGTIAVGNGLFKANPASLLSKCYPPKDPRLDGAFTLFYMSINIGSLIAL
SLAPVIADRFGYSVTYNLCGAGLIIALLVYIACRGMVKDIGSEPDFRPMS
FSKLLYVLLGSVVMIFVCAWLMHNVEVANLVLIVLSIVVTIIFFRQNKMF
VAFVLMLEAVVFYILYAQMPTSLNFFAINNVHHEILGFSINPVSFQALNP
FWVVLASPILAGILSMPMKFTLGMFMCSLGFLTAAAAGMWFADAQGLTSP
WFIVLVYLFQSLGELFISALGLAMIAALVMGFILGMWFLTQAAAFLLGGY
VATFTAVPDNITDPLETLPVYTNVFGKIGLVTLGVAVVMLLMVPWLKRMI
A
Ligand information
Receptor-Ligand Complex Structure
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PDB8b1b Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Y31 Y64 K123 Y149 N153 S156 Y285 N318 E393
Binding residue
(residue number reindexed from 1)		Y21 Y54 K113 Y139 N143 S146 Y266 N299 E364
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015078 proton transmembrane transporter activity
GO:0015333 peptide:proton symporter activity
GO:0022857 transmembrane transporter activity
GO:0042937 tripeptide transmembrane transporter activity
GO:0071916 dipeptide transmembrane transporter activity
GO:1904680 peptide transmembrane transporter activity
Biological Process
GO:0006857 oligopeptide transport
GO:0015031 protein transport
GO:0015833 peptide transport
GO:0035442 dipeptide transmembrane transport
GO:0035443 tripeptide transmembrane transport
GO:0042938 dipeptide transport
GO:0042939 tripeptide transport
GO:0055085 transmembrane transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b1b, PDBe:8b1b, PDBj:8b1b
PDBsum8b1b
PubMed37467108
UniProtP36837|DTPB_ECOLI Dipeptide and tripeptide permease B (Gene Name=dtpB)

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