Structure of PDB 8atw Chain A Binding Site BS01

Receptor Information
>8atw Chain A (length=922) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INFFEIYNSLPTLEEKKAFESALNIFNQDRQKVLENRATEAARERWKHDF
EEAKARGDISIEKNLNVKLWKWYNEMLPLVKEEINHCRSLLSEKLSDKKG
LNKVDTNRLGYGPYLTLIDPGKMCVITILELLKLNSTGGVIEGMRTARAV
ISVGKAIEMEFRSEQVLKKILWPQSIRARIGSVLISMLIQVAKVSVQGVD
PVTKAKVHGEAPAFAHGYQYHNGSKLGVLKIHKTLIRQLNGERLIASVQP
QLLPMLVEPKPWVNWRSGGYHYTQSTLLRTKDSPEQVAYLKAASDNGDID
RVYDGLNVLGRTPWTVNRKVFDVVSQVWNKGEGFLDIPGAQDEMVLPPAP
PKNSDPSILRAWKLQVKTIANKFSSDRSNRCDTNYKLEIARAFLGEKLYF
PHNLDFRGRAYPLSPHFNHLGNDMSRGLLIFWHGKKLGPSGLKWLKIHLS
NLFGFDKLPLKDRVAFTESHLQDIKDSAENPLTGDRWWTTADKPWQALAT
CFELNEVMKMDNPEEFISHQPVHQDGTCNGLQHYAALGGDVEGATQVNLV
PSDKPQDVYAHVARLVQKRLEIAAEKGDENAKILKDKITRKVVKQTVMTN
VYGVTYVGATFQIAKQLSPIFDDRKESLDFSKYLTKHVFSAIRELFHSAH
LIQDWLGESAKRISKSIRLDVDEKSFKNGNKPDFMSSVIWTTPLGLPIVQ
PYREESKKQVETNLQTVFISDPFAVNPVNARRQKAGLPPNFIHSLDASHM
LLSAAECGKQGLDFASVHDSYWTHASDIDTMNVVLREQFIKLHEVDLVLR
LKEEFDQRYKNYVKIGKLKRSTDLAQKIIRIRKDLSRKLGRSTTLADEIY
FEKKRQELLNSPLIEDRNVGEKMVTTVSLFEDITDLDALEGMSVLLPLRL
PEIPPKGDFDVTVLRNSQYFFS
Ligand information
Receptor-Ligand Complex Structure
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PDB8atw Structures illustrate step-by-step mitochondrial transcription initiation
Resolution3.62 Å
Binding residue
(original residue number in PDB)		L486 Y640 N642 G643 K645 Y1026 V1027 K1081
Binding residue
(residue number reindexed from 1)		L101 Y220 N222 G223 K225 Y606 V607 K661
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001018 mitochondrial promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003896 DNA primase activity
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0006269 DNA replication, synthesis of primer
GO:0006351 DNA-templated transcription
GO:0006390 mitochondrial transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0034245 mitochondrial DNA-directed RNA polymerase complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8atw, PDBe:8atw, PDBj:8atw
PDBsum8atw
PubMed37821701
UniProtP13433|RPOM_YEAST DNA-directed RNA polymerase, mitochondrial (Gene Name=RPO41)

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