Structure of PDB 8asw Chain A Binding Site BS01

Receptor Information
>8asw Chain A (length=1255) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRNLITLNKGKFKPTASTAEGDEDDLSFTLLDSVFDTLSDSITCVLGSTD
IGAIEVQQFMKDGSRNVLASFNIQTFDDKLLSFVHFADINQLVFVFEQGD
IITATYDPVSLDPAETLIEIMGTIDNGIAAAQWSYDEETLAMVTKDRNVV
VLSKLFEPISEYHLEVDDLKISKHVDPTMPYMVDTGDVTALDSHEITISW
RGDCDYFAVSSVEEVPDEDDETKSIKRRAFRVFSREGQLDSASEPVTGME
HQLSWKPQGSLIASIQRKTDLGEEDSVDVIFFERNGLRHGEFDTRLPLDE
KVESVCWNSNSEALAVVLANRIQLWTSKNYHWYLKQELYASDISYVKWHP
EKDFTLMFSDAGFINIVDFAYKMAQGPTLEPFDNGTSLVVDGRTVNITPL
ALANVPPPMYYRDFETPGNVLDVACSFSNEIYAAINKDVLIFAAVPSIEE
MKKGKHPSIVCEFPKSEFTSEVDSLRQVAFINDSIVGVLLDTDNLSRIAL
LDIQDITQPTLITIVEVYDKIVLLRSDFDYNHLVYETRDGTVCQLDAEGQ
LMEITKFPQLVRDFRVKRVHNTSAEDDDNWSAESSELVAFGITNNGKLFA
NQVLLASAVTSLEITDSFLLFTTAQHNLQFVHLNSTDFKPLPLVEEGVED
ERVRAIERGSILVSVIPSKSSVVLQATRGNLETIYPRIMVLAEVRKNIMA
KRYKEAFIVCRTHRINLDILHDYAPELFIENLEVFINQIGRVDYLNLFIS
CLSEDDVTKTKYKETLYSGISKSFGMEPAPLTEMQIYMKKKMFDPKTSKV
NKICDAVLNVLLSNPEYKKKYLQTIITAYASQNPQNLSAALKLISELENS
EEKDSCVTYLCFLQDVNVVYKSALSLYDVSLALLVAQKSQMDPREYLPFL
QELQDNEPLRRKFLIDDYLGNYEKALEHLSEIDKDGNVSEEVIDYVESHD
LYKHGLALYRYDSEKQNVIYNIYAKHLSSNQMYTDAAVAYEMLGKLKEAM
GAYQSAKRWREAMSIAVQKFPEEVESVAEELISSLTFEHRYVDAADIQLE
YLDNVKEAVALYCKAYRYDIASLVAIKAKKDELLEEVVDPGLGEGFGIIA
ELLADCKGQINSQLRRLRELRAKKEENPYAFYGQETEQADDVSVAPSETS
TQESFFTRYTGKTGGTAKTGASRRTAKNKRREERKRARGKKGTIYEEEYL
VQSVGRLIERLNQTKPDAVRVVEGLCRRNMREQAHQIQKNFVEVLDLLKA
NVKEI
Ligand information
>8asw Chain X (length=73) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gggcacauggcgcaguugguagcgcgcuucccuugcaaggaagaggucau
cgguucgauuccgguugcgucca
<<<<.<<..<<<<........>>>>.<<<<<.......>>>>>......<
<<<.......>>>>.>>.>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8asw Cryo-EM structure of the fully assembled Elongator complex.
Resolution3.96 Å
Binding residue
(original residue number in PDB)		S1205 E1208 S1209 F1211 T1212 Y1214 G1216 K1217 T1218 G1219 R1236 E1237 R1239 K1240 R1241 R1243
Binding residue
(residue number reindexed from 1)		S1150 E1153 S1154 F1156 T1157 Y1159 G1161 K1162 T1163 G1164 R1181 E1182 R1184 K1185 R1186 R1188
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0002098 tRNA wobble uridine modification
GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006417 regulation of translation
GO:0008033 tRNA processing
GO:0015031 protein transport
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0033588 elongator holoenzyme complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8asw, PDBe:8asw, PDBj:8asw
PDBsum8asw
PubMed36617428
UniProtQ06706|ELP1_YEAST Elongator complex protein 1 (Gene Name=IKI3)

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