Structure of PDB 8asg Chain A Binding Site BS01

Receptor Information
>8asg Chain A (length=1544) Species: 992210 (SFTS virus AH12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLEVLCGRINVENGLSLGEPGLYDQIYDRPGLPDLDVTVDATGVTVDIG
AVPDSASQLGSSINAGLITIQLSEAYKINHDFTFSGLRRLSEVFPITHDG
SDGMTPAVIHTRLDGTIVVVEFSTTRSHNIGGLEAAYRTKIEKYRDPISR
RVDIMENPRVFFGVIVVSSGGVLSNMPLTQDEAEELMYRFCIANEIYTKA
RSMDADIELQKSEEELEAISRALSFFSLFEPNIERVEGTFPNSEIKMLEQ
FLSTPADVDFITKTLKAKEVEAYADLCDSHYLKPEKTIQERLEINRCEAI
DKTQDLLAGLHARSNKQTSLNRGTVKLPPWLPKPSSESIDIKTDSGFGSL
MDHGAYGELWAKCLLDVSLGNVEGVVSDPAKELDIAISDDPEKDTPKEAK
ITYRRFKPALSSSARQEFSLQGVEGKKWKRMAANQKKEKESHETLSPFLD
VEDIGDFLTFNNLLTDSRYGDESIQRAVSILLEKASAMQDTELTHALNDS
FKRNLSSNVVQWSLWVSCLAQELASALKQHCRAGEFIIKKLKFWPIYVII
KPTKSSSHIFYSLGIRKADVTRRLTGRVFSDTIDAGEWELTEFKSLKTCK
LTNLVNLPCTMLNSIAFWREKLGVAPWLVRKPCSELREQVGLTFLISLED
KSKTEEIITLTRYTQMEGFVSPPMLPKPQKMLGKLDGPLRTKLQVYLLRK
HLDCMVRIASQPFSLIPREGRVEWGGTFHAISGRSTNLENMVNSWYIGYY
KNKEESTELNALGEMYKKIVEMEEDKPSSPEFLGWGDTDSPKKHEFSRSF
LRAACSSLEREIAQRHGRQWKQNLEERVLREIGTKNILDLASMKATSNFS
KDWELYSEVQTKEYHRSKLLEKMATLIEKGVMWYIDAVGQAWKAVLDDGC
MRICLFKKNQHREIYVMDANARLVQFGVETMARCVCELSPHETVANPRLK
NSIIENHGLKSARSLGPGSININSSNDAKKWNQGHYTTKLALVLCWFMPA
KFHRFIWAAISMFRRKKMMVDLRFLAHLSSKSESRSSDPFREAMTDAFHG
NRDVSWMDKGRTYIKTETGMMQGILHFTSSLLHSCVQSFYKSYFVSKLKE
GYMGESISGVVDVIEGSDDSAIMISIRPKSDMDEVRSRFFVANLLHSVKF
LNPLFGIYSSEKSTVNTVYCVEYNSEFHFHRHLVRPTLRWIAASHQISET
EALASRQEDYSNLLTQCLEGGASFSLTYLIQCAQLLHHYMLLGLCLHPLF
GTFMGMLISDPDPALGFFLMDNPAFAGGAGFRFNLWRACKTTDLGRKYAY
YFNEIQGHSVMVYWGDRKKYQALLNRMGLPEDWVEQIDENPGVLYRRAAN
KKELLLKLAEKVHSPGVTSSLSKGHVVPRVVAAGVYLLSRHCFRFSGSTQ
KASLIKLLMMSSISAMKHGGSLNPNQERMLFPQAQEYDRVCTLLEEVEHL
TGKFVVRERNIVRSRIDLFAEDLVSEVWFGEWDKLRASFAWLSTDPSETL
RDGPFLSHVQFRNFIAHRSVRLLGAPVTISQVVRMNFFPGFSLE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8asg Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		K849 A850 R920 I922 Y923 R930 Q933 Q1080 G1081
Binding residue
(residue number reindexed from 1)		K844 A845 R912 I914 Y915 R922 Q925 Q1072 G1073
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
Cellular Component
GO:0044165 host cell endoplasmic reticulum
GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0044177 host cell Golgi apparatus
GO:0044423 virion component

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8asg, PDBe:8asg, PDBj:8asg
PDBsum8asg
PubMed36651274
UniProtU3GU88

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