Structure of PDB 8asb Chain A Binding Site BS01

Receptor Information
>8asb Chain A (length=1715) Species: 992210 (SFTS virus AH12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLEVLCGRINVENGLSLGEPGLYDQIYDRPGLPDLDVTVDATGVTVDIG
AVPDSASQLGSSINAGLITIQLSEAYKINHDFTFSGLSKTTDRRLSEVFP
ITHDGSDGMTPAVIHTRLDGTIVVVEFSTTRSHNIGGLEAAYRTKIEKYR
DPISRRVDIMENPRVFFGVIVVSSGGVLSNMPLTQDEAEELMYRFCIANE
IYTKARSMDADIELQKSEEELEAISRALSFFSLFEPNIERVEGTFPNSEI
KMLEQFLSTPADVDFITKTLKAKEVEAYADLCDSHYLKPEKTIQERLEIN
RCEAIDKTQDLLAGLHARSNKQTSLNRGTVKLPPWLPKPSSESISGFGSL
MDHGAYGELWAKCLLDVSLGNVEGVVSDPAKELDIAISDYRRFKPALSSS
ARQEFSLQGVEGKKWKRMAANQKKEKESHETLSPFLDVEDIGDFLTFNNL
LTDSRYGDESIQRAVSILLEKASAMQDTELTHALNDSFKRNLSSNVVQWS
LWVSCLAQELASALKQHCRAGEFIIKKLKFWPIYVIIKPTKSSSHIFYSL
GIRKADVTRRLTGRVFSDTIDAGEWELTEFKSLKTCKLTNLVNLPCTMLN
SIAFWREKLGVAPWLVRKPCSELREQVGLTFLISLEDKSKTEEIITLTRY
TQMEGFVSPPMLPKPQKMLGKLDGPLRTKLQVYLLRKHLDCMVRIASQPF
SLIPREGRVEWGGTFHAISGRSTNLENMVNSWYIGYYKNKEESTELNALG
EMYKKIVEMEEDKPSSPEFLGWGDTDSPKKHEFSRSFLRAACSSLEREIA
QRHGRQWKQNLEERVLREIGTKNILDLASMKATSNFSKDWELYSEVQTKE
YHRSKLLEKMATLIEKGVMWYIDAVGQAWKAVLDDGCMRICLFKKNQHGG
LREIYVMDANARLVQFGVETMARCVCELSPHETVANPRLKNSIIENHGLK
SARSLGPGSININSSNDAKKWNQGHYTTKLALVLCWFMPAKFHRFIWAAI
SMFRRKKMMVDLRFLAHLSSKSESRSSDPFREAMTDAFHGNRDVSWMDKG
RTYIKTETGMMQGILHFTSSLLHSCVQSFYKSYFVSKLKEGYMGESISGV
VDVIEGSDDSAIMISIRPKSDMDEVRSRFFVANLLHSVKFLNPLFGIYSS
EKSTVNTVYCVEYNSEFHFHRHLVRPTLRWIAASHQISETEALASRQEDY
SNLLTQCLEGGASFSLTYLIQCAQLLHHYMLLGLCLHPLFGTFMGMLISD
PDPALGFFLMDNPAFAGGAGFRFNLWRACKTTDLGRKYAYYFNEISVMVY
WGDRKKYQALLNRMGLPEDWVEQIDENPGVLYRRAANKKELLLKLAEKVH
SPGVTSSLSKGHVVPRVVAAGVYLLSRHCFRFSQKASLIKLLMMSSISAM
KHGGSLNPNQERMLFPQAQEYDRVCTLLEEVEHLTGKFVERNIVRSRIDC
KAEDLVSEVWFGLKRTKLGPRLLKEEWDKLRASFAWLSTDPSETLRDGPF
LSHVQFRNFIAHVDSRSVRLLGAPTTISQVVRMNFFPGFSLEKSRTMTLC
LLSNYLSSRGGSILDQIERAQSGTLGGFSKPQKTFVRPGGGVGYKGKGVW
TGVMEDTHVQILIDGDGTSNWLEEIRLSSDARLYDVIESIRRLCDDLGIN
NRVASAYRGHCMVRLSGFKIKPASRTDGCPVRIMPDEVKMRVRGDILNLS
VTIQEGRVMNILSYR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8asb Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		K331 Q426 G427 E429 K431 K444 H447 H535 T558 K559 H563 F565 S600 K602 K656 G692 P693 R695 E763 N765 F1032 H1035 K1039 S1044 S1045 F1048 R1049
Binding residue
(residue number reindexed from 1)		K331 Q408 G409 E411 K413 K426 H429 H517 T540 K541 H545 F547 S582 K584 K638 G674 P675 R677 E745 N747 F1014 H1017 K1021 S1026 S1027 F1030 R1031
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
Cellular Component
GO:0044165 host cell endoplasmic reticulum
GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0044177 host cell Golgi apparatus
GO:0044423 virion component

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8asb, PDBe:8asb, PDBj:8asb
PDBsum8asb
PubMed36651274
UniProtU3GU88

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