Structure of PDB 8as6 Chain A Binding Site BS01

Receptor Information
>8as6 Chain A (length=1566) Species: 992210 (SFTS virus AH12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLEVLCGRINVENGLSLGEPGLYDQIYDRPGLPDLDVTVDATGVTVDIG
AVPDSASQLGSSINAGLITIQLSEAYKINHDFTFSGLSKTTDRRLSEVFP
ITHDGSDGMTPAVIHTRLDGTIVVVEFSTTRSHNIGGLEAAYRTKIEKYR
DPISRRVDIMENPRVFFGVIVVSSGGVLSNMPLTQDEAEELMYRFCIANE
IYTKARSMDADIELQKSEEELEAISRALSFFSLFEPNIERVEGTFPNSEI
KMLEQFLSTPADVDFITKTLKAKEVEAYADLCDSHYLKPEKTIQERLEIN
RCEAIDKTQDLLAGLHARSNKQTSLNRGTVKLPPWLPKPSSESIDIKTDS
GFGSLMDHGAYGELWAKCLLDVSLGNVEGVVSDPAKELDIAISDAKITYR
RFKPALSSSARQEFSLQGVEGKKWKRMAANQKKEKESHETLSPFLDVEDI
GDFLTFNNLLTDSRYGDESIQRAVSILLEKASAMQDTELTHALNDSFKRN
LSSNVVQWSLWVSCLAQELASALKQHCRAGEFIIKKLKFWPIYVIIKPTK
SSSHIFYSLGIRKADVTRRLTGRVFSDTIDAGEWELTEFKSLKTCKLTNL
VNLPCTMLNSIAFWREKLGVAPWLVRKPCSELREQVGLTFLISLEDKSKT
EEIITLTRYTQMEGFVSPPMLPKPQKMLGKLDGPLRTKLQVYLLRKHLDC
MVRIASQPFSLIPREGRVEWGGTFHAISGRSTNLENMVNSWYIGYYKNKE
ESTELNALGEMYKKIVEMEEDKPSSPEFLGWGDTDSPKKHEFSRSFLRAA
CSSLEREIAQRHGRQWKQNLEERVLREIGTKNILDLASMKATSNFSKDWE
LYSEVQTKEYHRSKLLEKMATLIEKGVMWYIDAVGQAWKAVLDDGCMRIC
LFKKNQEIYVMDANARLVQFGVETMARCVCELSPHETVANPRLKNSIIEN
HGLKSARSLGPGSININSSNDAKKWNQGHYTTKLALVLCWFMPAKFHRFI
WAAISMFRRKKMMVDLRFLAHLSSKSESRSSDPFREAMTDAFHGNRDVSW
MDKGRTYIKTETGMMQGILHFTSSLLHSCVQSFYKSYFVSKLKEGYMGES
ISGVVDVIEGSDDSAIMISIRPKSDMDEVRSRFFVANLLHSVKFLNPLFG
IYSSEKSTVNTVYCVEYNSEFHFHRHLVRPTLRWIAASHQISETEALASR
QEDYSNLLTQCLEGGASFSLTYLIQCAQLLHHYMLLGLCLHPLFGTFMGM
LISDPDPALGFFLMDNPAFAGGAGFRFNLWRACKTTDLGRKYAYYFNEIQ
GLSHSVMVYRKKYQALLNRMGLPEDWVEQIDENPGVLYRRAANKKELLLK
LAEKVHSPGVTSSLSKGHVVPRVVAAGVYLLSRHCFRFTQKASLIKLLMM
SSISAMKHGGSLNPNQERMLFPQAQEYDRVCTLLEEVEHLTGKFVVRERN
IVRSRIDLFQEPVDLRCKAEDLVSEVWFGLKRTKLGPRLLKEEWDKLRAS
FAWLSTDPSETLRDGPFLSHVQFRNFIAHVDAKSRSVRLLGAPVKKVTTI
SQVVRMNFFPGFSLEA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8as6 Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R318 G427 E429 K431 K444 H447 T558 K559 H563 S600 K656 R695 E763 N765 H1035 L1036 S1045 R1049
Binding residue
(residue number reindexed from 1)		R318 G418 E420 K422 K435 H438 T549 K550 H554 S591 K647 R686 E754 N756 H1021 L1022 S1031 R1035
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
Cellular Component
GO:0044165 host cell endoplasmic reticulum
GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0044177 host cell Golgi apparatus
GO:0044423 virion component

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8as6, PDBe:8as6, PDBj:8as6
PDBsum8as6
PubMed36651274
UniProtU3GU88

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