Structure of PDB 8as3 Chain A Binding Site BS01

Receptor Information
>8as3 Chain A (length=343) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYV
TLTCAFRYGVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGE
HAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFLAENLEEKIHK
RNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYH
GEPISVNVHVTNNTNKTVKKIKISVRQYADIVLFNTAQYKVPVAMEEADD
TVAPSSTFSKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREEI
LGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8as3 A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		T6 R7 V8 K10 K11 R25 R103 K107 L166
Binding residue
(residue number reindexed from 1)		T1 R2 V3 K5 K6 R20 R93 K97 L156
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0007165 signal transduction

View graph for
Biological Process
External links
PDB RCSB:8as3, PDBe:8as3, PDBj:8as3
PDBsum8as3
PubMed37244255
UniProtP49407|ARRB1_HUMAN Beta-arrestin-1 (Gene Name=ARRB1)

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