Structure of PDB 8as2 Chain A Binding Site BS01

Receptor Information

>8as2 Chain A (length=352) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYV
TLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLI
KKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFLAENLE
EKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDK
EIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADIVLFNTAQYKVPVAM
EEADDTVAPSSTFSKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTL
LREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPK
PK

Ligand information

>8as2 Chain B (length=4) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ASSV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8as2 A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	R7 V8 K10 Y21 K107
Binding residue (residue number reindexed from 1)	R2 V3 K5 Y16 K102

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0007165	signal transduction

View graph for
Biological Process

External links

PDB	RCSB:8as2, PDBe:8as2, PDBj:8as2
PDBsum	8as2
PubMed	37244255
UniProt	P49407\|ARRB1_HUMAN Beta-arrestin-1 (Gene Name=ARRB1)

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