Structure of PDB 8aqa Chain A Binding Site BS01

Receptor Information
>8aqa Chain A (length=40) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VDMYIERAGDITWEKDAEVTGNSPRLDVALDESGDFSLVE
Ligand information
Receptor-Ligand Complex Structure
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PDB8aqa Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2260
Resolution1.35 Å
Binding residue
(original residue number in PDB)		D83 F84
Binding residue
(residue number reindexed from 1)		D35 F36
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Cellular Component
GO:0044423 virion component

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Molecular Function
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Cellular Component
External links
PDB RCSB:8aqa, PDBe:8aqa, PDBj:8aqa
PDBsum8aqa
PubMed38809037
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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