Structure of PDB 8alz Chain A Binding Site BS01

Receptor Information
>8alz Chain A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RHPCDCLGQKHKLINNCLICGRIVCEQEGSGPCLFCGTLVCTHEEQDILQ
RDPLGVLVNPNMYQSPPQWVDHTGAASQKKAFRSSGFGLEFNSFQHQLRI
QDQEFQEGFDGGWCLSVHQPWASLLVRGIKRVEGRSWYTPHRGRLWIAAT
AKKPSPQEVSELQATYRLLRGKDVEFPNDYPSGCLLGCVDLIDCLSQKQF
KEQFPDISQESDSPFVFICKNPQEMVVKFPIKGNPKIWKLDSKIHQGAKK
GLMKQNKA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8alz Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8alz Cryo-EM structure of ASCC3 in complex with ASC1
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C171 C173 H178 C192
Binding residue
(residue number reindexed from 1)		C4 C6 H11 C25
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016922 nuclear receptor binding
GO:0019901 protein kinase binding
GO:0030331 nuclear estrogen receptor binding
GO:0035035 histone acetyltransferase binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0030520 estrogen receptor signaling pathway
GO:0032790 ribosome disassembly
GO:0045661 regulation of myoblast differentiation
GO:0045893 positive regulation of DNA-templated transcription
GO:0072344 rescue of stalled ribosome
GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016604 nuclear body
GO:0031594 neuromuscular junction
GO:0032991 protein-containing complex
GO:0099053 activating signal cointegrator 1 complex
GO:0180022 RQC-trigger complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8alz, PDBe:8alz, PDBj:8alz
PDBsum8alz
PubMed
UniProtQ15650|TRIP4_HUMAN Activating signal cointegrator 1 (Gene Name=TRIP4)

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