Structure of PDB 8adg Chain A Binding Site BS01

Receptor Information

>8adg Chain A (length=787) Species: 562 (Escherichia coli)

FVVKDIHFEGLQRVAVGAALLSMPVRTGDTVNDEDISNTIRALFATGNFE
DVRVLRDGDTLLVQVKERPTIASITFSGNKSVKDDMLKQNLEASGVRVGE
SLDRTTIADIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFQEGV
SAEIQQINIVGNHAFTTDELISHFQLRDEVPWWNVVGDRKYQKQKLAGDL
ETLRSYYLDRGYARFNIDSTQVSLTPDKKGIYVTVNITEGDQYKLSGVEV
SGNLAGHSAEIEQLTKIEPGELYNGTKVTKMEDDIKKLLGRYGYAYPRVQ
SMPEINDADKTVKLRVNVDAGNRFYVRKIRFEGNDTSKDAVLRREMRQME
GAWLGSDLVDQGKERLNRLGFFETVDTDTQRVPGSPDQVDVVYKVKERNT
GSFNFGIGYGTESGVSFQAGVQQDNWLGTGYAVGINGTKNDYQTYAELSV
TNPYFTVDGVSLGGRLFYNDFQADDADLSDYTNKSYGTDVTLGFPINEYN
SLRAGLGYVHNSLSNMQPQVAMWRYLYSMGEHPSTSDQDNSFKTDDFTFN
YGWTYNKLDRGYFPTDGSRVNLTGKVTIPGSDNEYYKVTLDTATYVPIDD
DHKWVVLGRTRWGYGDGLGGKEMPFYENFYAGGSSTVRGFQSNTIGPKAV
YFPHQASNYDPDYDYECATQDGAKDLCKSDDAVGGNAMAVASLEFITPTP
FISDKYANSVRTSFFWDMGTVWDTNWDSSQYSGYPDYSDPSNIRMSAGIA
LQWMSPLGPLVFSYAQPFKKYDGDKAEQFQFNIGKTW

Ligand information

>8adg Chain F (length=7) Species: 32630 (synthetic construct)

WNWTKRW

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8adg Darobactins Exhibiting Superior Antibiotic Activity by Cryo-EM Structure Guided Biosynthetic Engineering.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): N422 T423 G424 S425 F426 N427 F428 G429 Q446 L780
• Binding residue (residue number reindexed from 1): N399 T400 G401 S402 F403 N404 F405 G406 Q423 L757

Gene Ontology

Biological Process

• GO:0071709 membrane assembly

Cellular Component

• GO:0019867 outer membrane

External links

• PDB: RCSB:8adg, PDBe:8adg, PDBj:8adg
• PDBsum: 8adg
• PubMed: 36308277
• UniProt: P0A940|BAMA_ECOLI Outer membrane protein assembly factor BamA (Gene Name=bamA)