Structure of PDB 8aaa Chain A Binding Site BS01

Receptor Information
>8aaa Chain A (length=193) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSP
TKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVI
AWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVE
GFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP
Ligand information
>8aaa Chain B (length=17) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ACMFVPCAVRHALGLCA
Receptor-Ligand Complex Structure
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PDB8aaa Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		L453 L456 F457 E485 Y490 F491 L493 Q494 S495
Binding residue
(residue number reindexed from 1)		L118 L121 F122 E150 Y155 F156 L158 Q159 S160
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:8aaa, PDBe:8aaa, PDBj:8aaa
PDBsum8aaa
PubMed37328472
UniProtP0DTC2|SPIKE_SARS2 Spike glycoprotein (Gene Name=S)

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