Structure of PDB 8a9k Chain A Binding Site BS01

Receptor Information
>8a9k Chain A (length=998) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEEVEFVVEKALSMFSKMNLQEIPPLVYQLLVLSSKGSRKSVLEGIIAFF
SALDKQHNEEQSGDELLDVVTVPSGELRHVEGTIILHIVFAIKLDYELGR
ELVKHLKVGDSNNNLSPFSIALLLSVTRIQRFQDQVLDLLKTSVVKSFKD
LQLLQGSKFLQNLVPHRSYVSTMILEVVKNSVHSWDHVTQGLVELGFILM
DSYGPKKVSLSRMPNQHACKLGANILLETFKIHEMIRQEILEQVLNRVVT
RASSPISHFLDLLSNIVMYAPLVLQSCSSKVTEAFDYLSFLPLQTVQRLL
KAVQPLLKVSMSMRDCLILVLRKAMFANQLDARKSAVAGFLLLLKNFKVL
GSLLSVSQVHVDVHSHYNSVANETFCLEIMDSLRRCLSQQADVRLMLYEG
FYDVLRRNSQLANSVMQTLLSQLKQFYEPKPDLLPPLKLEACILTQKISL
QEPLDYLLCCIQHCLAWYKNTVIPFYEDLDDILESITNRMIKSELEDFEL
SADFSQSTSIGIKNNICAFLVMGVCEVLIEYNFSISSFSKNRFEDILSLF
MCYKKLSDILNEKATSDSLLSMKFVSSLLTALFRDSIQSHQESLSVLRSS
NEFMRYAVNVALQKVQQLKETGHVSGPDGQNPEKIFQNLCDITRVLLWRY
TSIPTGKSISLLCLEGLQKIFSAVQQFYQPKIQQFLRALDVSVTQRTAFQ
IRQFQRSLLNLLSSQEEDFNSKEALLLVTVLTSLSKLLEPSSPQFVQMLS
WTSKICKENSREDALFCKSLMNLLFSLHVSYKSPVILLRDLSQDIHGHLG
DIDQDVEVEKTNHFAIVNLRTAAPTVCLLVLSQAEKVLEEVDWLITKLKG
QVPNQPVEKAIIMQLGTLLTFFHELVQTALPSGSCVDTLLKDLCKMYTTL
TALVRYYLQVCQIPKNMEKLVKLSGSHLTPLCYSFISYVQNKSVATAMAR
VLRETKPIPNLIFAIEQYEKFLIHLSKKSKVNLMQHMKLSTSRDFKIK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8a9k Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		T1238 R1242
Binding residue
(residue number reindexed from 1)		T946 R950
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0070182 DNA polymerase binding
Biological Process
GO:0006281 DNA repair
GO:0031398 positive regulation of protein ubiquitination
GO:0036297 interstrand cross-link repair
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:1990391 DNA repair complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8a9k, PDBe:8a9k, PDBj:8a9k
PDBsum8a9k
PubMed36170365
UniProtQ9NVI1|FANCI_HUMAN Fanconi anemia group I protein (Gene Name=FANCI)

[Back to BioLiP]