Structure of PDB 8a5b Chain A Binding Site BS01

Receptor Information

>8a5b Chain A (length=220) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSE
QNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDAGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGI
YFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVK
MAKDRRNHCGIASAASYPTV

Ligand information

>8a5b Chain E (length=3) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

LLK

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8a5b Structural elucidation of antiviral cathepsin L inhibitors
Resolution	1.8 Å
Binding residue (original residue number in PDB)	G23 C25 E63 G67 G68 M161 D162
Binding residue (residue number reindexed from 1)	G23 C25 E63 G67 G68 M161 D162

Enzymatic activity

Enzyme Commision number

3.4.22.15: cathepsin L.

Gene Ontology

	Molecular Function
GO:0008234	cysteine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:8a5b, PDBe:8a5b, PDBj:8a5b
PDBsum	8a5b
PubMed	38630165
UniProt	P07711\|CATL1_HUMAN Procathepsin L (Gene Name=CTSL)

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