Structure of PDB 8a44 Chain A Binding Site BS01

Receptor Information
>8a44 Chain A (length=293) Species: 5855 (Plasmodium vivax) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NCNYKRKRRERDWDCNTKKDVCIPDRRYQLCMKELTNLVNNTDTNFHRDI
TFRKLYLKRKLIYDAAVEGDLLLKLNNYRYNKDFCKDIRWSLGDFGDIIM
GTDMEGIGYSKVVENNLRSIFGTDEKAQQRRKQWWNESKAQIWTAMMYSV
KKRLKGNFIWICKLNVAVNIEPQIYRWIREWGRDYVSELPTEVQKLKEKC
DGKINYTDKKVCKVPPCQNACKSYDQWITRKKNQWDVLSNKFISVKNAEK
VQTAGIVTPYDILKQELDEFNEVAFENEINKRDGAYIELCVCS
Ligand information
>8a44 Chain B (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
QLDFEDVWNSSYGVNDSFPDGDYDANLEA
Receptor-Ligand Complex Structure
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PDB8a44 Structural basis for DARC binding in reticulocyte invasion by Plasmodium vivax.
Resolution2.49 Å
Binding residue
(original residue number in PDB)		R274 I277 Y278 V282 Y293 R294 Y295 N296 K297 K301 R304 Q356 Y363 F373 I374 W375 I376 K378 V381
Binding residue
(residue number reindexed from 1)		R59 I62 Y63 V67 Y78 R79 Y80 N81 K82 K86 R89 Q141 Y148 F158 I159 W160 I161 K163 V166
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046789 host cell surface receptor binding
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8a44, PDBe:8a44, PDBj:8a44
PDBsum8a44
PubMed37336887
UniProtA5KDR7

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